The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for Dioxin (TCDD)Decreased testicular testosterone in those treated with 0.3 μg/kg. Decreased 3β-HSD1 at 1.0 μg/kg exposure levels |
Subjects: Sprague Dawley rats Chemical: Dioxin (TCDD) Low doses tested: 0.3 or 1.0 μg/kg bw Route of administration: dissolved in corn oil and administered orally Exposure duration: gestational day 11 – single dose (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 4) Age of measurement: gestational day 19.5 |
Reference [PubMed Link] Adamsson A, Simanainen U, Viluksela M, Paranko J, Toppari J. 2009. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis. Int J Androl 32(5):575-585. |