The weeks shown in color represent the start and end points of chemical exposure for each study.
| Study Results | Study Details | References |
Results for PFAS (K+PFOS)Decreases in total activity at 2 months of age. |
Subjects: NMRI mice Chemical: PFAS (K+PFOS) Low doses tested: 0.75 mg/kg bw Other doses tested: 11.3 mg/kg Route of administration: dissolved in a mixture of egg lecithin and peanut oil and delivered via metal gastric tube Exposure duration: post-natal day 10 – post-natal day 10 (comparable to human prenatal development from approximately day 1 of week 27 to day 1 of week 28) Age of measurement: 2 and 4 months of age |
Reference [PubMed Link] Johansson N, Fredriksson A, Eriksson P. 2008. Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice. Neurotoxicology 29(1):160-169. |
| Study Results | Study Details | References |
Results for PFAS (PFOA)Decreases in total activity and locomotion at 4 months; changes in activity compared to controls in response to nicotine. Increases in rearing in those dosed at 0.58 mg/kg PFOA at 2 and 4 months of age. |
Subjects: NMRI mice Chemical: PFAS (PFOA) Low doses tested: 0.58 mg/kg bw Other doses tested: 8.7 mg/kg bw Route of administration: dissolved in a mixture of egg lecithin and peanut oil and delivered via metal gastric tube Exposure duration: post-natal day 10 – post-natal day 10 (comparable to human prenatal development from approximately day 1 of week 27 to day 1 of week 28) Age of measurement: 2 and 4 months of age |
Reference [PubMed Link] Johansson N, Fredriksson A, Eriksson P. 2008. Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice. Neurotoxicology 29(1):160-169. |