What is TEDX? TEDX (The Endocrine Disruption Exchange, Inc.) is the only organization that focuses primarily on the human health and environmental problems caused by low-dose and/or ambient exposure to chemicals that interfere with development and function, called endocrine disruptors. Since antiquity, humans have known that some chemical substances in the environment can cause adverse health effects. For example, the Romans knew that sentencing prisoners to work in lead mines was a death sentence due to the toxicity of elemental lead.
We have learned over time that many chemical substances can cause a range of adverse health problems, including death, cancer, birth defects, and delays in development of cognitive functions. For instance, it is well established that asbestos can cause a fatal form of lung cancer, thalidomide can cause limb deformities, and breathing high concentrations of some industrial solvents can cause irreversible brain damage and death. Only relatively recently have we learned that a large number of chemicals can penetrate the womb and alter the construction and programming of a child before it is born. Through trans-generational exposure, endocrine disruptors cause adverse developmental and reproductive disorders at extremely low amounts in the womb, and often within the range of human exposure.
TEDX's work focuses on the endocrine system, which is the exquisitely balanced system of glands and hormones that regulates such vital functions as body growth, response to stress, sexual development and behavior, production and utilization of insulin, rate of metabolism, intelligence and behavior. Hormones are chemicals such as insulin, thyroxin, estrogen, and testosterone that interact with specific target cells. The interactions occur through a number of mechanisms, the easiest of which to conceptualize is through a lock and key arrangement. For example, target cells such as those in the uterus contain receptor anatomical areas (locks) into which specific estrogenic hormones can attach (key) and thereby cause specific biological actions, such as regulating ovulation or terminating pregnancy. As a matter of science, some synthetic chemicals such as polychlorinated biphenyls (PCBs), and their substitute, polybrominated diphenyl ethers (PBDEs), have been found to mimic this kind of cellular lock-key mechanism by locking onto a specific blood protein that ordinarily transports thyroid hormones throughout the body, blocking the function of the blood protein and thereby disrupting normal biological processes.
Why is TEDX unique? TEDX’s work is prevention driven, and it is the only environmental organization that focuses on the problems associated with endocrine disruption attributable to synthetic chemicals found in the general environment. While there are other national, international, and local organizations that address the public health and environmental consequences of toxic chemicals in the environment, none of them expressly emphasize endocrine disruption. By mainly focusing on substances in the environment that interfere with development and function throughout all life stages, TEDX has one of the most complete databases in the world on this topic, available for those concerned about public health and environmental quality. This database was developed because traditional toxicological protocols have used high doses on fully developed tissues and individuals that heretofore missed the consequences of chemical substances on developing tissues.
TEDX is unique because it focuses on the damaging activity of chemicals on biological systems from an entirely new approach. This new approach focuses on the effects of very low and ambient levels of exposure on developing tissue and resulting function before an individual is born, which can lead to irreversible, chronic disorders expressed at any time throughout the individual’s life. Endocrine disruption takes into consideration the vulnerability of every individual in the population during their most vulnerable life stages. By providing this unique perspective on the actions of endocrine disruptors, TEDX fills in the very large gap in public health protection that traditional toxicology and government regulatory agencies do not fill. Drawing upon its computerized databases on endocrine disruption and coordination with researchers in the field of endocrine disruption, TEDX provides the very latest summaries of the state of knowledge and its meaning for human health and the environment.
Why is TEDX needed? The human health consequences of endocrine disruption are dire. Yet, no chemical has been regulated in the U.S. to date because of its endocrine disrupting effects. The U.S. government has failed to respond to the evolving science of endocrine disruption. While much remains to be learned in regard to the nature and extent of the impact of endocrine disruptors on human health, enough is known now to assume a precautionary approach should be taken. TEDX provides concerned persons and organizations with a science-based foundation for individuals to act and promote responsive public policy-making. Moreover, as federal government resources devoted to research on endocrine disruption have diminished due to budget cuts, TEDX must assume an even more prominent role in developing and disseminating information on the human and environmental impacts of endocrine disruption.